Alcohol consumption is a major health issue and associated with human cancers,\nsuch as liver and breast cancers. Alcohol was classed as carcinogen to\nhuman by IARC. We have performed in vivo and in vitro studies which\ndemonstrate that diluted ethanol promotes cell proliferation and transformation\nand tumor formation. Consumption of liquor spirits (white wines) is a\npopular behavior. However, it is unclear whether liquor spirits affect cellular\nphenotypes of human cancers. At present study, we used diluted ethanol and\nliquor spirits (Sample #1 and Sample #2) to determine the changes in RNA\npolymerase III-dependent gene (Pol III gene) transcription, cell growth and\ncolony formation in the different human cancer lines. The results indicate that\nlow concentration of ethanol increases RNA Pol III gene transcription and\nrate of cell growth. However, both liquor spirits (Sample #1 and Sample #2)\ninhibit the activity of RNA Pol III genes and repress cell proliferation of the\ncancer lines, compared to diluted ethanol. The liquor spirits reduce the rate of\ncolony formation of human breast cancer cells and esophageal carcinoma\ncells. The inhibitions of the liquor spirits to RNA Pol III genes, cell growth\nand colony formation are in a dose-dependent manner. These new findings\nsuggest that the liquor spirits contain some active components to repress Pol\nIII gene transcription and cell growth caused by ethanol in different human\ncancer cells.
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